The Shephelah is very safe to travel. However, Though not as common as in the Negev desert, car theft is not uncommon.
If you go to a place that crosses the green line the line between the west bank and the rest of Israel, It is highly recommended to coordinate your trip with the Israeli army, hire an armed medic. If you are going on a guided tour with another group, they will probably hire the medic and coordinate the trip for you.
