Historic Gjirokaster is one of Albania's three UNESCO sites. The primary Regional Bus & Furgon Station in Gjirokaster is located at the entrance to the town, on the NW corner where the town's main boulevard intersects the National Road. It's less of a "bus station" and more of a collective gathering place for buses and furgons shared minibuses along the shoulder of the road. From here you can catch northbound buses to Tirana, Vlore, Fier, Berat, Tepelene, Korce, Permet, and southbound buses to Sarandë. International buses direct to Ioannina 5 Euro/ 7AM departure and Athens 20 Euro/ 8:30PM departure in Greece are available from the private bus agency offices found around the junction. A shuttle to the Kakavie border crossing with Greece runs several times a day.

Buses depart every day on the route Sarandë - Gjirokastër 300 leke stopping hourly at the bottom of the hill until the early afternoon. Buses and minibuses are going to Tirana 1000 leke every hour from around 7AM until 12noon, then there is a bus at 2:30PM and a night bus leaving at 11PM it arrives in Tirane at 5:45AM near Skanderbeg Square.

Transportation and other tourism information is available from the employees of the Tourism Information Center TIC, located in the old town, on the left side of the road leading towards the castle.