Humahuaca is dominated by the Monumento de la Independencia crowning a small rise just west of the center and reached by climbing a long flight of steps. At the top there is a nice view of the Rio Grande valley and the town center not marred by the statue. There is also an adobe belfry and several cactus plants, perhaps the most photographed site in northern Argentina.

The central plaza is bordered to its west by the lovely small Iglesia de la Candalaria y San Antonio, a colonial era foundation with an altarpiece dating to the late 17th century. Despite its small size, the church is a cathedral, one of the smallest churches to serve that function.

The center of the town is an attractively whitewashed Spanish colonial area. The church, now a cathedral, is well worth a visit.