By plane
By plane
Thai Airways (http://www.thaiair.com/) flies from Bangkok to Khon Kaen and back again three times a day.
By car
By car
It's easy to get to Khon Kaen by car. Just follow the four lane Hwy 2.
By bus
By bus
Buses to/from Bangkok's Northern Mo Chit Bus Terminal depart every 15 minutes from early until late.
For quicker service, avoid the touts at Mo Chit, and ask for Chan Tour. This company provides only VIP buses, which have very large seats and a bathroom. Alternatively Nakhon Chai Air 384 baht, highly recommended has nice VIP buses which are cleaner meals, drink, in-coach toilet than Chan but, with small seats. Nakhon Chai Air has a separate terminal from Mo Chit, about 1 km away. Nakhon Chai Air Website