International flights commonly come in to Milan or Rome, where one can rent a car and do the three-hour drive to Tuscany.
Florence and Pisa have important airports. Every major city has a railway station.
Pisa International Airport Galileo Galilei(http://www.pisa-airport.com/), located 1.5km 1 mile south of Pisa city centre.
Florence Airport Amerigo Vespucci(http://www.airport.floren...), Located four kilometers from the center of Florence.
Do note that Delta Airlines US Carrier now has a direct flight from New-York JFK to Pisa, offering a cheaper, alternative to flying into Florence.
Florence, Pisa and Grosseto are important rail destinations. Florence has two major rail stations, Santa Maria Novella SMN in the city center and Campo di Marte CdM a bit further away.
Connections from Florence to the rest of Italy by train are generally fast and frequent and EuroStar Italia services are available. Easy connections can be found to:
Cinque Terre reachable by train to La Spezia or Riomaggiore, or connecting from Genoa
Night train services are available from Florence to: