By far the easiest way to get to Siena from Florence though the train journey is much more picturesque. Take the SITA bus located in a small underground bus depot across the street, to the west of Santa Maria Novella train station. After 1hr 20 minutes it will arrive at the bus terminal at Piazza Antonio Gramsci which is located well within the walls of the city, allowing for an easy walk to any of the city's attractions. The cost is €7.80 May 2014.
Connections are also available from Rome 3 hours and various other cities.
Siena's Ampugnano airport is located 9 km from the city. At the moment, there are no scheduled air services to Siena airport. For additional information tel 0577-392226. A shuttle service connection is currently available between the airport and Piazza Gramsci TRA-IN tel. 0577-204224.
Most travellers arriving by plane will land at airports in Florence or Pisa. Buses of the Sena line connect Siena with the Bologna Marconi airport twice daily, 2.5 hours, a favorite with the discount carriers. There is also a bus link to Pisa airport.
From the north, trains go about hourly directly from Florence to Siena, and otherwise it is possible to take any train that stops in Empoli and find train connections from Empoli to Siena every 30-60 minutes. It costs €8.60 single Aug 2013. From the south, direct connections to Siena depart from Chiusi or from Grosseto. The train station in Siena is located approximately 2 km from Siena's historical centre follow directions "bus centro", you have to enter the mall to find the bus station to the city center, a five minute bus ride - buses leave regularly from Piazza del Sale. Buses numbers 3, 8, 10, 17, 77 leave from the station to Piazza del Sale and bus #17 departs from Piazza del Sale for the train station. If you don't mind walking uphill, you can also walk to the centre in about 20-30 minutes: Exit the train station, turn left, walk past the bus park and then uphill, bearing right at the traffic circle, staying on the road called Viale Giuseppe Manzini. Go through the city walls, and follow the road as it bends sharply to the right. The road becomes Via Garibaldi, which will take you into the city.
From the north, take the Chiantigiana from Florence SS 222 - 72 km that elegantly crosses the hills of Chianti or the highway SS 2 superstrada Siena/Firenze - 68 km. From the south, Siena can be reached by taking the Autoway from Rome A1 Roma-Firenze, exit Valdichiana, turning right on state highway #326 Bettolle-Siena - 240 km. Relatively cheap parking can be found near Fortezza Medicea, northwest of the city stadium - and around it. (http://www.slowtrav.com/I...) (http://www.turismoverde.c...) (http://www.frommers.com/d...)