On the A1 Autostrada that connects Rome and Florence, exit at Chiusi coming from the south and Val di Chiana when coming from the north. From Val di Chiana take the SS73 in the direction of Perugia. Leaving at Chiusi you have to pass through the town of Chiusi before following signs to Trasimeno on the SS71.There is a railway line from Perugia to Terontola-Cortona, that passes to the north of the lake with stations at Magione, Torricella, Passignano and Tuoro sul Trasimeno. At Terontola this line connects with the main line between Rome and Florence.
