Being close to Bologna and Milano, the main hubs for train traffic in the north of Italy, it's relatively easy to reach Reggio Emilia by train.The train station within walking distance from the city center, and relatively safe compared to major cities train stations.From Milano and Bologna it's possible to book expensive and fast Eurostar trains, or just jump - without reservation - on a Regional train slower, probably a bit dirty, but definitely cheaper.
Reggio Emilia is located on the Highway A1, that runs from Milano to Napoli, passing by Bologna, Firenze and Roma.Leaving from Milano the exit for Reggio Emilia is around 130, 140 km south. Coming from Bologna, the exit for Reggio Emilia is aroung 80 km north. The Milano-Reggio highway is usually busy even in the evening and early morning, but it's not so common to be stuck in a long queue for long periods of time. On the other hand, going from Reggio Emilia to Bologna, or passing Bologna, with the highway, can be a pain sometimes, because of traffic and roadworks.