Because of its central location, Ede is easily reached by car, using the A12 from Utrecht and Arnhem and the newly finished A30 from Amersfoort and Apeldoorn. The A12 may be quite congested during rush hours.
You can also use the train to reach Ede, since it's on the major line between Amsterdam and Arnhem. It's only about 25 minutes from Utrecht and about an hour from Amsterdam.
As a short-distance alternative there are some bus lines linking Ede to other cities around it.