Langdon Hall
A luxurious country inn in an old estate toward the northwest side of Cambridge. Surprisingly luxurious, considering it's neither in the middle of nowhere you can hear the 401 nor in a big city. Excellent food, though quite expensive.
Best Western Cambridge
730 Hespeler Rd.
519-622-1180
Holiday Inn Cambridge
200 Holiday Inn Dr.
519-658-4601
There are a large number of chain hotels near the 401/Hespeler Road interchange. More unique places to sleep in Cambridge can also be found, however.