Cacibajagua.
Great rock music, nice decor, adult crowd. sanchez #201. (http://www.colonialzone-d...)
Santo Domingo has an amazing variety of night life options. Unfortunately, most bars and clubs must close at midnight from Sunday to Thursday and at 2AM on Friday and Saturday. This is a regulation imposed since 2006 intended to curtail the escalating crime in the city. Therefore, it is not uncommon for people to start partying at 8PM on the weekends. Happily, the regulation is suspended on holidays and the last two weeks of December for Christmas partying. Usually the clubs located inside major hotels are exempt from this rule, although they aren't usually much fun.
As of November 2007, there are a couple of bars that are open until 3AM on weekends since August 2007.
The Malecon is home to several options as well, depending on what's in style at the time.
Check out Jet Set on Monday nights for live Merengue and Bachata shows from the most popular top bands.
Head over to the upscale side of Santo Domingo Naco, Piantini if that is your scene. There are a ton of options there, including perennial favorites such as Trio Caffe, Praia and Montecristo. Be aware that those kind of places can have a rather strict admission policy, you usually have to look white enough and rich enough to be admitted. This discrimination hasn't go unnoticed, the Embassy of United States directed all resident official U.S. Embassy employees to refrain from patronizing Loft one of the most popular and exclusive nightclubs in the city, responding to the actions of Loft management in selectively denying entry to African-Americans embassy on July 22 2007. (http://usemb.gov.do/prele...)
In this upscale area of Santo Domingo, consider: