There will be a constant flow of buses along the Interamericana Highway. Some of them will be branching off onto minor roads to more remote areas. Going through these roads can be a exhausting experience, particularly in northen Huehuetenango and Quiche regions but scenery makes it well worth the travel. The most recommended plan is to base yourself in one of the larger city or village and then make a series of day-trips to those more remote areas.