By bus
Bus #11 (http://mta.maryland.gov/s...) has a remarkably useful route leading north on Charles St from Downtown and the Inner Harbor, and on to the Baltimore Museum of Art and Johns Hopkins' main campus in North Baltimore. On the way south back to the Inner Harbor, it follows Maryland Ave to Cathedral St, before heading east all the way to Fells Point and Canton.
The Charm City Circulator's purple route is a really useful loop for any visitors. It runs a loop from Penn Station through the district, Downtown, the Inner Harbor, and even on to Federal Hill. Just remember that it doesn't run that late!
By Metro
The metro (http://mta.maryland.gov/s...) has a convenient stop at State Center near the Cultural Centre light rail stop, but it's not terribly clear whether anyone uses the Baltimore metro, nor whether you should either.
By train
Amtrak (http://amtrak.com) as well as the MARC commuter rail Penn Line [mta.maryland.gov/services/marc/schedulesSystemMaps/penn.cfm] from D.C. serve Penn Station, which is a fairly easy walk from virtually anywhere in the district.
By Light Rail
The light rail (http://mta.maryland.gov/s...) leads through Mount Vernon and Station North, stopping at Centre St for Mt Vernon Square, Cultural Centre for the Opera House, Penn Station, and North Ave for the eccentric bars, clubs, and pizza places at the northern edge of the district.
By car
It's easy enough to find the neighborhood by carâyou can take Martin Luther King Blvd straight from Exit 53 off I-95N, or simply go straight up Charles St from Downtown. I-83, the Jones Falls Expressway, leads right into the district and has exits at North Ave and Maryland Ave/Charles St/St. Paul.
Parking is another matter, with often limited metered parking in the busy sections around Charles St, and two hour zone restrictions in residential areas. The zone restrictions are pretty poorly enforced, but the ticket prices can be high.