Southeast Baltimore is not served by either the metro or light rail lines of the MTA. You'll have to walk, use the MTA buses, or drive.
By Water Taxi
For a unique and scenic way of getting there from the Inner Harbor, the water taxi (http://thewatertaxi.com/i...) can drop you off at several locations along the Fell Point or Canton waterfronts.
By bus
The MTA serves the Southeast Baltimore region from Inner Harbor and Downtown via routes #7, #10, #11 and #20.
If you are arriving to Baltimore by bus services such as Greyhound or the so-called Chinatown buses from Philadelphia and Washington D.C., they may drop off or pick up passengers at the Baltimore Travel Plaza, located near where O'Donnell St crosses the I-95. From there, MTA bus #20 will take visitors Downtown.
On foot
Assuming you're walking through Southeast Baltimore from the Inner Harbor, Canton is about a thirty to forty minute walk, and Greektown will take at least an hour.
By car
Car may be the most convenient way of getting to Southeast Baltimore if you have access to one. If you're traveling to Baltimore from elsewhere on the Atlantic coast by way of Interstate 95 I-95, you will pass through Southeast Baltimore. The highway passes through Greektown and just outside the eastern edge of the Canton neighborhood.