Southern Maryland is served by three regional airports: Washington Reagan National, Dulles International, and Thurgood Marshall Baltimore-Washington International.
The major driving routes to the area from Washington, DC include Route 4 Calvert Country and Route 5 Charles and St. Mary's Counties. From points south, take Route 301. From points north, take I-95 South to the Washington Beltway I-495 and follow the Inner Loop to either the Route 4 or Route 5 exit.
There are no passenger rail lines serving Southern Maryland.