One of the highlights of this region is the Salar de Uyuni: 200 square miles of flat dazzling white salt at an altitude of 3000 metres. There are many tours of this salt lake from Uyuni - or for a four day tour choose the one from Tupiza near the Argentine border. There are many fascinating islands on the lake with giant cactii growing everywhere.
Another highlight in the bolivian altiplano are the highland lagunas in the southeast near the border to Chile. Most known is the Laguna Colorada (http://www.travelpic.de/G...) and also the Laguna Verde (http://www.travelpic.de/G...) as well as the Ãrbol de Piedra.