By bus
Manizales Bus Station Terminal de Transportes is a modern facility located next to the lower cable car station. The cable car can take you to the city centre for 1400 pesos great views. Shared taxis to Chinchina cost 3000 pesos per person and take about 40 mins. Buses to Pereira take about 1h15m and cost 10,000 pesos. Buses to Medellin take about 4h30m with a short stop and cost 30,000 pesos.
Service in the 'upscale' buses is very good and they are very comfortable. Pick the most expensive service just a couple of dollars extra as these buses tend to be newer and better mechanical condition.
Currently buses run in and out of Manizales's main station, Terminal de Transporte de Manizales. The station is clean and has standard amenities. Multiple bus companies have regular routes to destinations around the country. To get there from the airport you can take a taxi ride.
Some common bus companies in Colombia that are found in this Terminal are:
Expreso Bolivariano Expreso Bolivariano- This company has one of the most extensive networks. Some international destinations as well.
Coomotor (http://www.coomotor.com.co/) Mostly destinations in Southern Colombia
You will find many others there.
By plane
The city is served by La Nubia Airport ICAO: SKMZ, IATA: MZL ~10 minutes from downtown in a taxi, that receives domestic flights of Avianca, Aires, ADA airlines. There are non-stop flights to MedellÃn and Bogotá. It features WiFi access to the Internet from almost every location. Taxis are regulated, reasonably priced and safe from the airport. A taxi ride from the airport to the center takes approximately 20 minutes, and can cost $5.00 USD.